NEW PIPERAZINES AS ANTIMALARIAL DRUGS Russian patent published in 2015 - IPC C07D213/64 C07D295/185 A61K31/496 A61P33/06 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to compounds of the structural formula I

which can be used for treating and/or preventing malaria caused by Plasmodium falciparum. In formula I: X means CH or N, R¹ means -NO₂, -N(CH₃)₂ or -NCH₃(CH₂CH₂OH) and R² means hydrogen, methyl, ethyl, n-propyl, isopropyl, tert-butyl, cyanogroup, halogen, methoxygroup, ethoxygroup, n-propoxygroup, isopropoxygroup, trifluoromethyl, difluoromethoxygroup, methylsulphonyl, acetyl or acetylaminogroup; or X means CH, R¹ means hydrogen and R² means ethyl, isopropyl, tert-butyl, ethoxygroup, n-propoxygroup, isopropoxygroup, methylsulphonyl, acetylaminogroup or methoxycarbonyl; or X means CH, R¹ means a cyanogroup and R² means ethyl, isopropyl, tert-butyl, ethoxygroup, n-propoxygroup, isopropoxygroup, trifluoromethyl, difluoromethoxygroup, trifluoromethoxygroup, methylsulphonyl or acetylaminogroup; or X means CH, R¹ means chlorine and R² means ethyl, isopropyl, tert-butyl, ethoxygroup, n-propoxygroup, isopropoxygroup, difluoromethoxygroup, methylsulphonyl or acetylaminogroup; or X means CH, R¹ means a methoxygroup or isopropoxygroup and R² means trifluoromethyl; or X means CH, R¹ means methylsulphonyl or ethylsulphonyl and R² means trifluoromethyl, ethyl, isopropyl, tert-butyl, ethoxygroup, n-propoxygroup, isopropoxygroup or difluoromethoxygroup.

EFFECT: invention refers to a pharmaceutical composition containing the above compounds, and to using the compounds for preparing the pharmaceutical composition.

22 cl, 2 tbl, 73 ex