BIOPRINTER Russian patent published in 2015 - IPC C12M3/00 

FIELD: biotechnology.

SUBSTANCE: bioprinter comprises the unit of cell reprogramming and the unit of output of the cells on the substrate, as well as the successively connected unit of loading and storing the colony of somatic cells, the unit of cell reprogramming with a device of inclusion of one or more reprogramming factors and a device of inclusion of methyltransferase inhibitor GSK126, mounted on it, having a reprogramming compartment, a unit of culturing the pluripotent stem cells with a device of insertion of the agent modifying the epigenetic status of the cell, the device of insertion of protein Bax, the device of insertion of protein Bak, the device of insertion of nitrogen monoxide, the device of insertion of proliferation inhibitor, and the device of insertion of apoptosis inhibitor, having a compartment of cell culturing, and a mechanism of changing the nutrient medium for the cells, a unit of cell differentiation with a device of insertion of one or more growth factors, mounted on it, having a compartment of cell differentiation, a unit of storage of differentiated cells, having a compartment of storage of differentiated cells, a unit of output of the cells on the substrate with a device of hydrogel insertion on the substrate, mounted on it, made with the ability to operate according to the principle of three-dimensional ink jet printer, and a control system.

EFFECT: invention provides the ability to print organs and tissues without signs of carcinogenesis, without the necessity in use of additional equipment.

3 cl, 2 dwg