FIELD: chemistry.
SUBSTANCE: method consists in the interaction of a carbonyl compound with an acetonitrile derivative in the presence of an alkali solution in a solvent medium with the following extraction and purification of the target product. The method is characterised by the fact that interaction is carried out in an ethanol medium at a temperature of 20-30°C in the presence of a water solution of an alkali, representing sodium hydroxide. As the carbonyl compound benzaldehyde or 3-phenoxybenzaldehyde is applied and as the acetonitrile derivative - 3- phenoxyphenylacetonitrile. The process is carried out with the molar ratio of the carbonyl compound, 3- phenoxyphenylacetonitrile and alkali equal to 1:1:0.5. The target product is extracted by filtration; purification is realised by re-crystallisation from ethanol.
EFFECT: method makes it possible to obtain target compounds in mild conditions with good output and high degree of purity.
2 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR PREPARING 3-SUBSTITUTED-3-(3-PHENOXYPHENYL)-2-PROPENENITRILES | 2008 |
|
RU2366647C1 |
| METHOD OF PRODUCING 2-(3-PHENOXYPHENYL-SUBSTITUTED)BENZIMIDAZOLES | 2011 |
|
RU2453539C1 |
| METHOD OF PRODUCING 3-PHENOXYPHENYLACETONITRILE | 2011 |
|
RU2451669C1 |
| METHOD OF PRODUCING 6-(3-PHENOXYPHENYL-SUBSTITUTED) 2,4-DIAMINO-SIMM-TRIAZINES | 2011 |
|
RU2451678C1 |
| METHOD FOR PREPARING SUBSTITUTED 3-META-PHENOXYPHENYL-1-PHENYL-2-PROPENE-1-ONES | 2004 |
|
RU2266895C1 |
| METHOD OF PRODUCING 2-(3-PHENOXY PHENYL-SUBSTITUTED)BENZOXAZOLES | 2011 |
|
RU2473546C2 |
| METHOD OF PRODUCING ETHYL 5-METHYL-3-(3-PHENOXYPHENYL)-1-PHENYL-1H-PYRAZOLYL-4-CARBOXYLATE | 2015 |
|
RU2582127C1 |
| PROCESS FOR PREPARING 2-(3-PHENOXYPHENYL)-PROPRIONIC ACID OR ITS CALCIUM SALT | 0 |
|
SU1039439A3 |
| 3-PHENOXYPHENYL-CONTAINING 1,3-DIKETONES AS STARTING COMPOUNDS FOR PRODUCING CHELATE COMPLEXES THEREOF WITH COPPER (II) IONS AND METHOD OF PRODUCING 3-PHENOXYPHENYL-CONTAINING 1,3-DIKETONES | 2012 |
|
RU2475473C1 |
| METHOD FOR PREPARING 1-META-PHENOXYPHENYL-2-NITROALKENES | 2004 |
|
RU2263661C1 |
