METHOD FOR PREPARING 3-SUBSTITUTED-3-(3-PHENOXYPHENYL)-2-PROPENENITRILES Russian patent published in 2009 - IPC C07C253/00 C07C253/16 C07C255/54 

FIELD: medicine.

SUBSTANCE: invention refers to preparation of new intermediate products of -3-substituted-3-(3-phenoxyphenyl)-2-propenenitriles of general formula 1 which can be used in production of biologically active substances, including insecticides, or in production of pharmacologically active compounds. The method for preparing -3-substituted-3-(3-phenoxyphenyl)-2-propenenitriles of general formula 1 where R=H, CH3, consists in reaction of carbonyl compound chosen from 3-phenoxybenzaldehyde or 3-phenoxyphenylmethylketone and acetonitrile with potassium hydroxide added and an end product to be recovered. Preferentially, process is implemented at mole ratio of carbonyl compound, acetonitrile and potassium hydroxide equal to 1:(20-22):1 respectively, in initial acetonitrile medium at boiling temperature 80-82°C. As a rule, the end product is recovered by extraction with diethyl ether. Vacuum distillation is used to distil the extractant and purify the end product.

EFFECT: high-yield and high-purity products.

2 cl, 2 ex