METHOD FOR PREDICTION OF RISK OF DEVELOPING RACHITISM IN INFANTS SUFFERING THYROID INSUFFICIENCY Russian patent published in 2015 - IPC G01N33/74 

FIELD: medicine.

SUBSTANCE: method involves biochemical serum test to measure parathyroid hormone (PTH), calcitonin (CT) and vitamin D (25OHD3), thyreotropic hormone (TTH) and thyroid hormone (free T4) in newborns with the test to be repeated 3 months later. If the minimum thyroid insufficiency tends to persist (high TTG concentration more than 3.4 mcIU/ml and/or lowered free T4 below 10 pmole/ml), whereas PHT grows by 25-30%, CT decreases by 15-20%, 25OHD3 decreases by 40-50% in relation to the initial values, a risk of rachitism is stated that enables performing early pre-clinical diagnosis of the disease. The presented method enables considering the hormonal reaction of calcium-regulating and hypophyseal-thyreoid systems, performing the pre-clinical diagnosis of rachitism, predicting a risk, a clinical course, a severity of the disease, determining the necessary volume of an adequate therapy (dosage) timely and the length thereof in the infants suffering rachitism accompanied by thyroid insufficiency. Using the presented method enables detecting the group of outpatient children pertaining to the prophylaxis for the purpose of performing timely therapeutic actions aiming at reducing a risk of rachitism and bone pathologies.

EFFECT: method is easy to use and interpret the results, can be used by a wide range of general paediatricians, provides monitoring the quality of the therapeutic actions performed.

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