METHOD OF OBTAINING VIRAL ANTIGEN AND VACCINES Russian patent published in 2015 - IPC C12N7/00 A61K39/42

Abstract RU 2565827 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: claimed invention relates to pharmaceutical industry. Claimed are: method of obtaining viral antigen from enveloped virus and application of said method in production of vaccine preparation, containing said viral antigen. Claimed method includes obtaining and clarification of liquid, which contains enveloped virus, obtaining concentrated liquid product, solubilisation of enveloped virus, present in concentrated liquid product, separation of viral antigen and its purification. Stage of solubilisation of enveloped virus, present in concentrated liquid product, follows immediately after stage of obtaining concentrated liquid product. Stage of solubilisation is realised by addition of detergent or mixture of detergent, containing cationic detergent. Claimed method of isolation makes it possible to obtain high output of isolated viral antigen with minimal number of stages, with obtained viral antigen being of high purity. Claimed method of obtaining viral antigen can be used in pharmaceutical industry for obtaining vaccine preparation.

EFFECT: method improvement.

28 cl, 2 dwg, 9 tbl, 4 ex

Similar patents RU2565827C2

Title	Year	Author	Number
METHOD FOR PRODUCING PREPARATION CONTAINING VIRAL ANTIGENS AND USING PREPARATION	2008	Kistner Otfrid Tauehr Krista Barrett Noehl' Mundt Vol'Fgang	RU2496519C2
METHOD OF PREPARING SURFACE ANTIGEN PROTEINS FROM INFLUENZA VIRUS, ANTI-INFLUENZA VACCINE	1998	Van Skharrenburg Gjustaf J.M. Brands Rudi	RU2197264C2
METHOD FOR OBTAINING A TETRAVALENT VACCINE FOR THE PREVENTION OF INFLUENZA	2020	Katlinskij Anton Vikentevich Shkunova Natalya Borisovna Vandyshev Pavel Evgenevich Afanasev Stanislav Vadimovich	RU2754398C1
VACCINE AGAINST INFLUENZA AND METHOD FOR ITS PREPARATION	2013	Zagidullin Nail' Vilenovich Israfilov Azamat Gabdel'Akhatovich Gelich Ljudmila Vjacheslavna Kyzin Andrej Aleksandrovich Erastova Natal'Ja Pavlovna	RU2523614C1
METHOD OF PRODUCING VACCINE ANTIGENS, OBTAINED VACCINE ANTIGENS AND USE THEREOF	2015	Rosa-Calatrava, Manuel Traversier, Aurelien Dejean, Emmanuel Desuzinges-Mandon, Elodie	RU2703147C2
METHOD FOR PREPARING INACTIVATED VACCINE AGAINST HEPATITIS A VIRUS	2006	Muntjanova Marija Alekseevna Nemtsov Jurij Vasil'Evich Krjuk Natal'Ja Ivanovna Jashin Valerij Viktorovich Nikulin Leonid Georgievich Kuslij Aleksandr Georgievich Mironenko Vjacheslav Vladimirovich Jasudis Galina Vladimirovna Guseva Irina Aleksandrovna Molokeev Aleksej Vladimirovich	RU2314125C1
FUNCTIONALLY RECONSTRUCTED ADJUVANT-CONTAINING VIRUS MEMBRANES	2004	Stegmann Antonius Jokhannes Khendrikus Vilskhut Jan Kristian Van Berkum Jokhannes Khenrikus Gerardus	RU2348428C2
INFLUENZA VIRUS THE VIRUS-LIKE PARTICLE AND ITS OBTAINING METHOD	2018	Doronin Aleksandr Nikolaevich	RU2681439C1
METHOD OF PRODUCING A POLYVALENT INFLUENZA VACCINE	2018	Doronin Aleksandr Nikolaevich	RU2701953C1
MULTIVALENT INFLUENZA VACCINE	2018	Doronin Aleksandr Nikolaevich	RU2706191C1

RU 2 565 827 C2

Authors

Tsuj In'-Tsin

Van Idin

Tus Jo

Van'T Khof Ron

Skhaker Sabakh

Van Roehj Gert'E Jakoba

Dates

2015-10-20—Published

2012-07-04—Filed