METHOD OF PRODUCING VACCINE ANTIGENS, OBTAINED VACCINE ANTIGENS AND USE THEREOF Russian patent published in 2019 - IPC C12N7/04 C07K14/11 

FIELD: biotechnology.

SUBSTANCE: invention relates to the field of biotechnology. Invention is a method for preparing a vaccine influenza virus antigen, comprising a step of fragmenting a biological membrane associated with said vaccine antigen by bringing said biological membrane into contact with at least one calixarene, where the influenza virus is selected from influenza A and influenza viruses B, further comprising a stage of dialysis vaccine antigen; an influenza virus vaccine comprising an effective amount of the influenza virus vaccine antigen produced by the method, as per any of cl. 1–4, calixarene of formula (II) in form of an excipient in amount of 0.1 to 1000 mcg of the total weight of the vaccine and a pharmaceutically acceptable carrier; use of calixarene of formula.

EFFECT: invention widens the spectrum of agents for producing vaccine antigens.

8 cl, 4 dwg, 8 tbl, 5 ex