FIELD: medicine.
SUBSTANCE: invention refers to medicine, particularly to laboratory diagnostics, and makes it possible to detect a red blood cell ability to generate nitric oxide (NO). A method involves taking a blood sample from an examined individual, mixing the sample with an anticoagulant, placing a half of the sample into a hypoxic environment, then producing blood plasma from the sample portions affected and unaffected by the hypoxic environment, measuring the nitric oxide content in both portions and calculating a difference of the measured values as compared to similar findings in a reference group. The comparison results show the NO-generating red blood cell function state.
EFFECT: method enables sizing up a contribution of the enhanced or diminished NO-generating red blood cell function to a pathogenic mechanism of hypertensive disease and other disorders related to hypoxic and thrombotic conditions, disturbed vascular control and abnormal nitric oxide metabolism.
5 cl, 2 tbl, 2 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF ASSESSING INDIVIDUAL BIOAVAILABILITY OF NITRIC OXIDE IN CEREBRAL MICROANGIOPATHY (SMALL VESSEL DISEASE) | 2023 |
|
RU2812240C1 |
| POLYFUNCTIONAL POLYHEMOGLOBIN-ENZYME COMPLEX | 2010 |
|
RU2432172C1 |
| METHOD OF ESTIMATING FUNCTIONAL STATUS OF ENDOTHELIUM IN PATIENT WITH ARTERIAL HYPERTENSION AND ITS CEREBRAL COMPLICATIONS | 2008 |
|
RU2380705C1 |
| INCLUSION COMPLEXES OF DERIVATIVES OF 1,2,5-OXA- -DIAZOLE-2-OXIDE WITH POLYCYCLIC DERIVATIVES OF GLUCOPYRANOSE, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION | 2001 |
|
RU2186782C1 |
| METHOD OF ORGAN PROTECTION IN CARDIOSURGICAL INTERVENTIONS ACCOMPANIED BY CIRCULATORY ARREST | 2019 |
|
RU2729506C1 |
| COMPOSITION POSSESSING ENDOTHELIAL PROTECTIVE, VASODILATING AND ANGIOPROTECTIVE EFFECT | 2011 |
|
RU2464019C1 |
| ISOTONIC CRYSTALLOID AQUEOUS SOLUTION | 2017 |
|
RU2739561C2 |
| METHOD FOR PREDICTING INFLAMMATION IN DEBUT OF RHEUMATOID ARTHRITIS | 2002 |
|
RU2245556C2 |
| METHOD FOR EVALUATING VASCULAR WALL ENDOTHELIUM CAPACITY TO PRODUCE AND SECRETE NITROGEN MONOXIDE | 1999 |
|
RU2157089C1 |
| DONOR OF NITROGEN OXIDE ACTIVATING SOLUBLE FORM OF GUANYLATE CYCLASE, INHIBITING PLATELET AGGREGATION AND EXHIBITING SPASMOLYTIC AND VASODILATING EFFECT | 2001 |
|
RU2208438C1 |
