FIELD: biotechnology.
SUBSTANCE: production of modified influenza virus proteins in plants has been described. The influenza hemagglutinin (HA) protein may comprise an amino acid sequence containing at least one substitution compared to the corresponding wild-type amino acid sequence. In addition, nucleic acids encoding a modified HA protein are provided. In addition, methods of producing an influenza virus-like particle (VLP) and methods of increasing the yield of production of an influenza virus-like particle (VLP) in a plant, a plant part, or a plant cell are also provided.
EFFECT: invention makes it possible to increase the production of influenza virus-like particles (VLPs) in plants, the VLPs containing modified influenza viral proteins, such as modified HA.
19 cl, 1 dwg, 6 tbl, 4 ex
| Title | Year | Author | Number |
|---|---|---|---|
| HEMAGLUTININ MUTANTS OF THE INFLUENZA VIRUS | 2019 |
|
RU2801708C2 |
| HEMAGLUTININ MUTANTS OF INFLUENZA VIRUS | 2019 |
|
RU2809237C2 |
| INCREASING VARIABLE-FREE PARTICLES OUTPUT IN PLANTS | 2012 |
|
RU2682752C2 |
| OBTAINING VIRUS-LIKE PARTICLES OF INFLUENZA VIRUS IN PLANTS | 2014 |
|
RU2742607C1 |
| OBTAINING VIRUS-LIKE PARTICLES OF INFLUENZA VIRUS IN PLANTS | 2014 |
|
RU2705555C2 |
| HEMAGGLUTININ-CONTAINING CHIMERIC VIRUS-LIKE PARTICLES, SIMILAR TO PARTICLES OF FLU VIRUS | 2010 |
|
RU2569195C9 |
| PRODUCTION OF VIRUS-LIKE PARTICLES IN PLANTS | 2011 |
|
RU2655431C2 |
| GENETICALLY CONSTRUCTED DEPENDENT ON PYRROLOQUINOLINQUINONE GLUCOSODEHYDROGENASE, CONTAINING INSERTION OF AMINO ACID | 2005 |
|
RU2336306C1 |
| MUTANTS FAD-2 AND HIGHLY OLEIC PLANTS | 2007 |
|
RU2484137C2 |
| IMMUNOGENIC EPITOPE OF INFLUENZA VIRUS | 2009 |
|
RU2546872C2 |
