METHOD FOR ASSESSING FUNCTIONAL HEALTH OF COLLAGEN TISSUE Russian patent published in 2016 - IPC A61B1/07 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, urology, dentistry, gynaecology, X-ray diagnostics, laryngology and can be used to assess the functional health of collagen tissues, particularly collagen fibres of mucosal stroma. An internal structure of the collagen tissue is analysed at a depth of up to 2 mm by means of cross-polarised optical coherence tomography (CP-OCT); an OCT-image (OCT-I) of the analysed tissue are examined in orthogonal and straight polarisations; an average OCT-signal (OCT-S) and an average background signal are calculated in orthogonal polarisation; OCT-S value that is a difference of the average OCT-S in orthogonal polarisation and the average background OCT-S is derived, and the functional health of the tissue is assessed. The OCT-I is potentiated in orthogonal and straight polarisations to produce OCT-S power in relative units; the produced potentiated OCT-I is averaged in a transverse coordinate; the average background signal is deducted from the average OCT-S in orthogonal polarisation. That is followed by relating the OCT-S powers averaged in the transverse coordinate in orthogonal and straight polarisations. This relation is averaged in a longitudinal coordinate along the whole probing depth, for which the OCT-S power in orthogonal polarisation exceeds the average background OCT-S by a double standard deviation of the background OCT-S. The derived value is an integral depolarisation factor (IDF), which is used to assess the functional health of the examined collagen tissue. The normal IDF of the buccal mucosa makes more than from 0.08 to 0.09; the same value accompanying an acute inflammation is 0.03-0.05; with a fibrous tissue formation, it is 0.10-0.13; and one with a fibrosis-scar tissue is from 0.13 to 0.17. The normal IDF of the urinary bladder mucosa makes more than from 0.08 to 0.12; in an acute inflammation, it is more than 0.05 to 0.07; in a fibrous tissue formation, it is more than 0.11 to 0.17; in severe epithelium dysplasia - from 0.03 to 0.05; in epidermoid cancer with the onset of invasive growth - from 0.01 to 0.02. The normal IDF of the postoperative scar tissue of the urinary bladder makes more than 0.17 to 0.27, and in cancer, on the postoperative scar - from 0.03 to 0.09.

EFFECT: method provides the more accurate assessment of the functional health of the collagen tissue of mucosal stroma of the above body areas in the differential diagnostics of the above conditions.

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