DERIVATIVES OF VITAMINE B6 NUCLEOTIDES, ACYCLIC NUCLEOTIDES AND ACYCLIC NUCLEOSIDE PHOSPHONATES Russian patent published in 2018 - IPC A61K31/675 A61P35/00 C07F9/38 C07F9/36 C07H19/20 

Abstract RU 2640582 C2

FIELD: pharmacology.

SUBSTANCE: invention relates to compounds, compositions thereof, for treatment of infections and neoplasms with structures , where R1 is the residue of a compound selected from the group consisting of cytarabine, fludarabine, gemcitabine, clofarabine, cladribine, vidase, dacogen, pentostatin and cladribine or aristermycin, acyclovir, ganciclovir, penciclovir, adefovir, cidofovir, tenofovir, zidovudine and lamivudine; X and Y are independently O, S or NH; and R2 and R3 are independently selected from the group consisting of H, alkyl, phenyl, heteroaryl and the remainder of the vitamin B6 fragment selected from

wherein heteroaryl is an aromatic ring containing from 1 to 3 heteroatoms selected from oxygen, sulfur and nitrogen, and wherein at least one of R2 and R3 is the residue of a fragment of vitamin B6, L is alkyl.

EFFECT: new effective substances for treatment of viral and oncological diseases.

16 cl, 4 dwg, 2 tbl, 6 ex

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RU 2 640 582 C2

Authors

Karpeisky Alexander

Zinnen Shawn

Urlam Murali

Vvedensky Vladimir Y.

Guzaev Andrei P.

Dates

2018-01-10Published

2012-08-01Filed