FIELD: bioengineering.
SUBSTANCE: suggested strain is produced based on cells Escherichia coli BL21 (DE3) and contains plasmide DNA pETDuet-1, comprising the gene from which the protein CRM197 is produced, and additionally the gene is produced and used to synthesize methionine aminopeptidase E. coli, wherein the genes are codon optimised for expression in cells E. coli, and the synthesis of two proteins is performed simultaneously.
EFFECT: increased immunogenicity of vaccines.
1 dwg, 4 ex
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