DIAGNOSTIC TECHNIQUE FOR DISPOSITION TO ATHEROSCLEROSIS PROGRESSION IN PATIENTS WITH CHRONIC ISCHEMIC HEART DISEASES BY PERIPHERAL BLOOD INTERLEUKIN-10-PRODUCING LYMPHOCYTE COUNT Russian patent published in 2016 - IPC G01N33/50 

Abstract RU 2575791 C1

FIELD: medicine.

SUBSTANCE: invention represents a diagnostic technique for a disposition to atherosclerosis progression in patients with chronic ischemic heart disease involving sample analysis to measure an interleukin-10-producing T-lymphocyte count, characterised by recovering a mononuclear cell fraction from the peripheral blood, activating the cells in a culture, conducting lymphocyte phenotyping with the use of fluorescent anti-CD4 and interleukin-10 (IL-10) antibodies, and performing flow cytometry; the IL-10-producing T-lymphocyte (CD4+IL-10+ cell) count expressed as a percentage (%) of CD4+ lymphocytes of less than 3.5% is indicative of the high risk of atherosclerosis progression.

EFFECT: higher effectiveness of a method for detecting the patients prone to atherosclerosis progression.

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RU 2 575 791 C1

Authors

Aref'Eva Tat'Jana Igorevna

Balakhonova Tat'Jana Valentinovna

Krasnikova Tat'Jana Leonidovna

Noeva Elena Aleksandrovna

Potekhina Aleksandra Viktorovna

Provatorov Sergej Il'Ich

Pylaeva Ekaterina Alekseevna

Ruleva Natal'Ja Jur'Evna

Dates

2016-02-20Published

2014-10-13Filed