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RU

(11)

2 813 686

(13)

C1

(51)

IPC

G01N33/49(2006-01-01)

G01N33/577(2006-01-01)

(21) (22)

Application

2023115206, 2023-06-09

(24)

Start date

2023-06-09

(22)

Actual filing date

2023-06-09

(45)

Published

2024-02-15

(72)

Inventor

Kologrivova Irina ViacheslavovnaSuslova Tatiana EvgenevnaKoshelskaia Olga AnatolevnaKharitonova Olga AnatolevnaKravchenko Elena SergeevnaTrubacheva Oksana Aleksandrovna

(73)

Holder

Federalnoe Gosudarstvennoe Biudzhetnoe Nauchnoe Uchrezhdenie Natsionalnyi Issledovatelskii Meditsinskii Tsentr Rossiiskoi Akademii Nauk» Nimts)

METHOD OF DIAGNOSING METAINFLAMMATION IN PATIENTS WITH CORONARY HEART DISEASE AND TYPE 2 DIABETES MELLITUS Russian patent published in 2024 - IPC G01N33/49 G01N33/577 

Abstract RU 2813686 C1

FIELD: medicine; immunology; cardiology and endocrinology.

SUBSTANCE: invention can be used to diagnose metainflammation in patients with coronary heart disease and type 2 diabetes mellitus. The relative content of CD4+CD25lowFoxP3+ T-regulatory lymphocytes from all CD4+ lymphocytes of peripheral blood is determined. Based on the absolute content of lymphocytes obtained during a general blood test, the absolute content of CD4+CD25lowFoxP3+ T-regulatory lymphocytes in the peripheral blood is calculated. With a total absolute content of CD4+CD25lowFoxP3+ T-regulatory lymphocytes in peripheral blood 1.39×107 cells/l or more metainflammation is diagnosed.

EFFECT: method provides diagnostics of metainflammation in patients with coronary heart disease and type 2 diabetes mellitus by determining the total absolute content of CD4+CD25lowFoxP3+ T-regulatory lymphocytes 1.39×107 cells/l or more in peripheral blood.

1 cl, 1 dwg, 1 tbl, 3 ex

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RU 2 813 686 C1

Authors

Kologrivova Irina Viacheslavovna

Suslova Tatiana Evgenevna

Koshelskaia Olga Anatolevna

Kharitonova Olga Anatolevna

Kravchenko Elena Sergeevna

Trubacheva Oksana Aleksandrovna

Dates

2024-02-15—Published

2023-06-09—Filed

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