METHOD FOR NONINVASIVE EVALUATION OF RESERVE MYOCARDIAL PERFUSION Russian patent published in 2016 - IPC A61B6/03 A61K49/06 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, radionuclide diagnostics, is intended for detection of coronary insufficiency in multivascular injury, as well as a functional test in selection method of treating ischemic heart disease. Can be used in heart disease department, therapeutic and diagnostic institutions equipped with radioisotope laboratories. One performs dynamic SPECT emission computed tomography with radiopharmaceutical (RP) ^{99 m}Tc-methoxy-isobutyl-isonitrile, recording passage of a bolus of RP in conditions of rest and with underlying pharmacological load. Scintillation score of the left ventricular cavity (LV) is examined together with crown, front, rear, side and left ventricular septal regions in a dose of RP 185 Mbq under conditions of rest and dose RP 740 Mbq with underlying pharmacological load (FN) adenosine introduced intravenously in a dose of 160 mcg/kg/min. Average value of counting pulses with the investigated area of infarction in conditions of rest and with underlying FN. Area under curve that reflects passage of bolus of RP at left ventricular cavity under conditions of rest and with underlying FN. Myocardial blood flow reserve index (RCC) for each of said regions of LV by formula: iRMK = (Cs/Ss)/(Cr/Sr), where iRMK is myocardial blood flow reserve index; CS-average value of pulse counting from the left ventricular myocardium during loading sample; SS is the area under curve that reflects passage bolus RP at left ventricular cavity at loading sample; CR-average value of pulse counting from the left ventricular myocardium in conditions of rest; SR is the area under curve that reflects passage bolus RP at left ventricular cavity, in conditions of rest. If the RCC index in estimated area of LV is less than 1.5, in the given region of LV it is considered to be low.

EFFECT: method provides non-invasiveness and accurate assessment of the IMC at reduced time of examination and radiation exposure on the patient.

1 cl, 8 dwg, 2 ex