SUBSTITUTED CINNAMAMIDE DERIVATIVE, METHOD FOR PRODUCTION AND USE THEREOF Russian patent published in 2016 - IPC C07D317/60 C07D317/64 A61K31/36 A61P25/00 

FIELD: chemistry.

SUBSTANCE: present invention relates to derivatives of substituted cinnamamide, namely compositions of general formula (I) or pharmaceutically acceptable acid addition salts, where R₁ represents OH, F, Cl, Br, I, OCH₃, OCF₃, OCHF₂, OCH₂F, CF₃, CHF₂, CH₂F, CH₃, CH₃CH₂, CF₃CH₂, NO₂; n equals 0, 1, 2 or 3, and elementary link includes at least one single or double carbon-carbon bond; X denotes =O, =S; Y is N or NR₃, where said R₃ is H, C₁~C₁₀hydrocarbyl with straight chain; C₃~C₁₀hydrocarbyl with branched chain; R₂ represents h, C₁~C₁₀hydrocarbyl with unbranched chain,group C₃~C₁₀hydrocarbyl with branched chain, or R₂ represents group which forms tetrahydropirrol, piperidyl or hexamethylenimin group with adjacent Y; at that when n equals 1, R₁ is not OH and OCH₃, as well as methods of their obtaining, according to which derivatives of substituted Piperonal is selected as source materials for producing derivatives of substituted cinnamamide by Wittig reaction and condensation of acid with amine.

EFFECT: invention also relates to pharmaceutical composition based on compounds of formula I and use thereof for preventing and treating of depressive type mental illnesses.

14 cl, 5 tbl, 15 ex