FIELD: biochemistry.
SUBSTANCE: antisense oligonucleotides that modulate expression of specified gene of Sodium channel, voltage-gated, alpha subunit (SCNA) in vivo or in vitro as compared to normal control are described. Oligonucleotides are phosphorothioate analogs with length from 11 to 30 nucleotides comprising at least one modification selected from: modified sugar residue; modified internucleotide bond; modified nucleotides and their combinations; wherein said oligonucleotides are compounds specifically hybridised with a complementary region of natural antisense oligonucleotide of sodium channel, voltage-gated, alpha subunit (SCNA) gene.
EFFECT: use of said oligonucleotides for treatment of diseases and disorders associated with expression of SCNA gene.
33 cl, 22 dwg, 2 tbl, 21 ex
| Title |
Year |
Author |
Number |
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2011 |
- Kollard Dzhozef
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| TREATMENT OF DISEASES ASSOCIATED WITH FRATAXIN (FXN), BY INHIBITING NATURAL ANTISENSE FXN TRANSCRIPT |
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|
RU2611190C2 |
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2011 |
- Kollard Dzhozef
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|
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| TREATMENT OF INTERFERON-RELATED DEVELOPMENTAL REGULATOR 1 (IFRD1) ASSOCIATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO IFRD1 |
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|
RU2611195C2 |
| TREATMENT OF DISEASES ASSOCIATED WITH THE SIALIDASE 4 (NEU4) GENE, BY GENE NEU4 NATURAL ANTISENSE TRANSCRIPT INHIBITION |
2011 |
- Kollard Dzhozef
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|
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|
RU2620978C2 |
| TREATMENT OF PANCREATIC DEVELOPMENTAL GENE RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO PANCREATIC DEVELOPMENTAL GENE |
2011 |
|
RU2612161C2 |
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2011 |
- Kollard Dzhozef
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|
RU2608493C2 |
| TREATING SIRTIUN 1 (SIRT1)-RELATED DISEASES BY INHIBITON OF NATURAL ANTISENSE TRANSCRIPT |
2009 |
- Kollard, Dzhozef
- Khor'Kova Sherman, Ol'Ga
- Kojto, Karlush
- De Leon, Belinda
|
RU2551234C2 |
