TREATMENT OF DISEASES, ASSOCIATED WITH PROTEIN OF PROSTATE APOPTOTIC RESPONSE PAR4, BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT OF PAR4 GENE Russian patent published in 2016 - IPC C12N15/113 

FIELD: chemistry.

SUBSTANCE: invention relates to biochemistry. Disclosed are methods for increasing expression of PAR4 polynucleotide, including realisation of contact with at least one oligonucleotide from 15 to 30 nucleotides long, which is aimed at natural antisense sequence for PAR4 polynucleotide, and said natural antisense sequence has sequence, represented in SEQ ID NO: 2. Claimed is synthetic modified oligonucleotide, from 15 to 30 nucleotides long, and pharmaceutical composition, containing said oligonucleotide. disclosed is method for apoptosis induction in biological system, expressing or with acquired ability to express products of PAR4 genes, which includes introduction of oliginucleotide from 15 to 30 nucleotides long into said system, which is aimed as natural antisense sequence SEQ ID NO: 2 of PAR4 polynucleotide and increases expression of said PAR4 polynucleotide.

EFFECT: invention makes it possible to increase PAR4 polynucleotide expression.

28 cl, 6 dwg, 1 tbl, 3 ex