FIELD: biotechnology.
SUBSTANCE: invention relates to biotechnology, particularly to a method of producing glial precursors derived from induced pluripotent stem cells with increased expression of NGF for therapy of neurodegenerative diseases.
EFFECT: invention provides obtaining a cell culture of modified glial precursors, which demonstrates expression of glial marker s100β, stimulates increased survival rate of cerebellar neurons and has pronounced antiamnestic action due to increased secretion of neurotrophin NGF.
1 cl, 2 dwg, 3 tbl, 3 ex
| Title | Year | Author | Number |
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| EVALUATION METHOD OF MORPHOFUNCTIONAL STATE OF INDUCED PLURIPOTENT STEM CELLS OF PARKINSONIAN PATIENTS, WHICH ARE DIFFERENTIATED TO DOPAMINERGIC NEURONS | 2012 |
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| METHOD FOR PREPARING A NOOTROPIC COMPOSITION BASED ON POLYPEPTIDE COMPLEXES ISOLATED FROM NEURONS AND GLIAL CELLS OBTAINED BY DIRECTIONAL DIFFERENTIATION OF INDUCED HUMAN PLURIPOTENT STEM CELLS | 2018 |
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RU2690498C1 |
