FIELD: medicine.
SUBSTANCE: invention refers to medicine and can be used for diagnosing and treating male sterility in infertile patients, as well as for in vitro fertilization programs due to rejection of sperm samples containing cells with disturbed chromatin packaging. Method of determining anomalies of human spermatozoon chromatin packing in male infertility disclosed in the invention involves determining the DNA quantity in insoluble and soluble chromatin and calculating their percentage according to the formula: 
boundary pathology value of insoluble chromatin (ICC)% - 76.0±3.0, soluble chromatin - 24.0±3.0.
EFFECT: technical result achieved at implementation of the developed invention is higher accuracy of determining anomalies of spermatozoon chromatin packing in male sterility.
1 cl, 1 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF DIAGNOSING ABNORMAL CHROMATIN PACKING IN MALE STERILITY AND DIAGNOSTIC AGENT FOR DETERMINING MALE STERILITY | 2014 |
|
RU2582914C2 |
| DIAGNOSTIC TECHNIQUE FOR ABNORMAL CHROMATIN PACKAGING IN MALE INFERTILITY | 2009 |
|
RU2426993C2 |
| DIAGNOSTIC TECHNIQUE FOR ABNORMAL CHROMATIN PACKAGING IN MALE INFERTILITY | 2010 |
|
RU2437100C1 |
| METHOD FOR DIAGNOSIS OF ABNORMAL SPERM CELL DIFFERENTIATION IN MALE STERILITY IN SYSTEM | 2014 |
|
RU2584592C1 |
| METHOD OF INFERTILITY DIAGNOSTICS FOR MEN | 2008 |
|
RU2371720C1 |
| METHOD OF SPERMATOZOID SAMPLE PREPARATION FOR ELECTRONIC MICROSCOPY | 2008 |
|
RU2371718C1 |
| METHOD FOR ASSESSING THE QUALITY OF EJACULATE BY THE CONTENT OF SPERMATOZOA WITH HYDROXYMETHYLATED DNA | 2017 |
|
RU2673472C1 |
| METHOD OF DETERMINING TREATMENT TACTICS FOR INFERTILITY ASSOCIATED WITH HUMAN PAPILLOMAVIRUS INFECTION IN MEN | 2023 |
|
RU2806807C1 |
| METHOD FOR DIAGNOSING EJACULATE FERTILITY IN IDIOPATHIC INFERTILITY | 2022 |
|
RU2789239C1 |
| METHOD OF THE MALE STERILITY DIAGNOSIS | 1997 |
|
RU2118822C1 |
