HAMBOGENIC ACID DERIVATIVES, SYNTHESIS METHOD THEREOF AND USE Russian patent published in 2016 - IPC C07D493/20 A61K31/352 A61P35/00 

FIELD: chemistry.

SUBSTANCE: invention relates to derivatives of hambogenic acid corresponding to structural formulae (I) or (II), where A is -CO- or -HC(OH)-; R² hydrogen or a straight or branched C₁-C₁₀ alkyl group; R³ hydrogen or acyl group, substituted with C₁-C₁₀ alkyl group; R is hydrogen or a straight or branched C₁-C₁₀ alkyl group; R¹ is selected from: -OR⁴, or ; in which R⁴ is selected from a group consisting of any of the following: hydrogen, straight or branched C₁-C₁₀ alkyl group or an alkyl group, possibly containing from 1 to 3 substituted groups, including oxygen, C₁-C₁₀ alkoxy group or with C₁-C₁₀ alkoxycarbonyl group; R⁵ and R⁶ are independently selected from any of the following substituted groups: hydrogen; straight or branched C₁-C₁₀ alkyl group or with C₁-C₁₀ alkyl group, possibly containing from 1 to 3 substituted groups, including oxygen, C₁-C₁₀ alkoxy group, C₁-C₁₀ alkoxyacyl group, C₁-C₁₀ alkyl group, substituted with phenyl; s and t are integer positive numbers, and sum of s and t is a natural number from 2 to 4; m is 0, 1, 2 or 3 and represents a number of substituted groups with R⁷ rings; n is 0, 1, 2 or 3 and represents B on the ring; B is carbon, nitrogen or oxygen; B is carbon, groups R⁷, R⁸ are identical to group R⁵; and R⁴, R³, R², R¹ and are not simultaneously hydrogen as indicated in Formula (I). Invention also relates to methods of producing compounds of formulae I and II and intermediate compounds and to anticancer pharmaceutical composition based on these compounds.

EFFECT: in comparison with hambogenic acid derivatives hambogenic acid exhibit effective anticancer activity.

13 cl, 5 dwg, 2 tbl, 28 ex