CATIONIC ETHER OF L-NITROARGININE CATIONIC TYPE AS INHIBITOR OF MITOCHONDRIAL SYNTHASE OF NITROGEN OXIDE Russian patent published in 2016 - IPC A61K31/198 A61P43/00 

Abstract RU 2600159 C1

FIELD: medicine.

SUBSTANCE: invention refers to medicine and concerns an agent inhibiting mitochondrial synthase of nitrogen oxide, representing an ether of L-nitroarginine cationic type, namely, choline ester of L-nitroarginine, carnitine ether of L-nitroarginine, triphenylphosphonium hexyl ether of L-nitroarginine.

EFFECT: invention provides better survival rate in comparison with the prototype (6-Nitroindazole) of experimental animals with cerebrovascular disorders, later onset of cramps and considerable increase in lifetime of experimental animals in hypercapnic hypoxia.

1 cl, 3 tbl, 3 ex

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RU 2 600 159 C1

Authors

Chepur Sergej Viktorovich

Pluzhnikov Nikolaj Nikolaevich

Khurtsilava Otari Givievich

Nakatis Yakov Aleksandrovich

Chubar Oleg Vladimirovich

Bykov Vladimir Nikolaevich

Anokhin Aleksandr Gennadevich

Pavlova Lyudmila Vasilevna

Fateev Ivan Vladimirovich

Bakulina Larisa Sergeevna

Razumova Dina Vladimirovna

Dates

2016-10-20Published

2015-07-27Filed