METHOD OF PRODUCING A PHARMACEUTICAL ERYTHROMYCIN COMPOSITION Russian patent published in 2016 - IPC A61K31/7048 A61K47/34 A61K9/48 A61J3/02 A61J3/07 

FIELD: medicine.

SUBSTANCE: invention relates to medicine and chemical-pharmaceutical industry and a method of producing a new pharmaceutical erythromycin composition in the form of capsules for use as a broad-spectrum antibiotic. Method of producing a pharmaceutical composition for treating bacterial and protozoal infectious diseases in the form of enterosoluble erythromycin-based capsules comprises mixing erythromycin base or its pharmaceutically acceptable salt with pluronic at a ratio of 70:30, micronization of produced mixture, addition of auxiliary substances, repeated micronization and filling gelatine capsules with the produced mixture. Kolliphor P 188, Kolliphor P 407 or their mixture are used as a pluronic.

EFFECT: method is high-tech, and the produced composition and dosage form have high bioavailability of about 70 %, sufficient for considerable reduction of preparation dose (up to 2 g a day) and maintaining a stable erythromycin concentration in blood.

6 cl, 3 ex, 2 tbl