FIELD: chemistry.
SUBSTANCE: invention relates to organic chemistry, particularly to a method of producing pentaoxaspyroalkanes of general formula (1) involving 1,1-1,1-bis(hydroperoxy)cycloalkanes (where the cycloalkane is cyclopentane, or cyclohexane or cycloheptane or cyclooctane or cyclododecane) reaction with formaldehyde in presence of catalyst Sm(NO3)3·6H2O, and the molar ratio of 1,1-bis(hydroperoxy)cycloalkane : formaldehyde of Sm(NO3)3·6H2O = 10:20:(0.3-0.7), at room temperature (20 °C) and atmospheric pressure in tetrahydrofuran as a solvent for 4-6 hours.
EFFECT: these compounds can be used as preparations having an antimalarial activity; the output of pentaoxaspyroalkanes (1) is equal to 65-97 %.
1 cl, 1 tbl, 1 ex
(1)
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