FIELD: chemistry.
SUBSTANCE: invention relates to a process for the preparation of 9-aryl-6,7,11,12-tetraox-9-azaspiro[4.7]dodecanes of general formula (1)
,
in which o-, m-, p-fluoroanilines are reacted with 6,7,9,11,12-pentaoxaspiro[4.7]dodecane in the presence of a catalyst Sm(NO3)3⋅6H2O at a molar ratio of fluoroaniline: 6,7,9,11,12-pentaoxaspiro[4.7]dodecane:Sm(NO3)3⋅6H2O = 10:(10–12):(0.3–0.7) at room temperature (20 °C) and atmospheric pressure for 4–6 hours in tetrahydrofuran.
EFFECT: method for the preparation of 9-aryl-6,7,11,12-tetraox-9-azaspiro[4.7]dodecanes of the general formula (1) in a high yield is proposed.
1 cl, 1 tbl, 1 ex
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