FIELD: pharmaceutics.
SUBSTANCE: invention relates to method of producing novel compounds of class of spiro{pyrano[2,3-d]pyrimidin-5,3′-pyrroles}, namely 7-amino-2,2′,4-trioxo-5′-phenyl-1,1′,2,2′,3,4-hexahydrospiro{pyrano[2,3-d]pyrimidin-5,3′-pyrrol}-6-carbonitriles of general formula I, where R1=COOEt, Ph; R2=CH2Ph, C6H11-c, H, by reaction between 5-phenyl-1H-pyrrol-2,3-diones with malononitrile and barbituric acid in presence of triethylamine in inert aprotic solvent.
EFFECT: obtaining novel compounds, which can be used as initial products for synthesis of novel heterocyclic systems and in pharmacology as those exhibiting antimicrobial activity.
3 cl, 1 tbl, 3 ex
| Title |
Year |
Author |
Number |
| ETHYL-2-AMINO-7,7-DIMETHYL-2',5-DIOXO-5'-PHENYL-1',2',5,6,7,8-HEXAHYDROSPIRO[CHROMEN-4,3'-PYRROL]-4'-CARBOXYLATES AND METHOD FOR PRODUCING THEM |
2010 |
- Dmitriev Maksim Viktorovich
- Silajchev Pavel Sergeevich
- Maslivets Andrej Nikolaevich
- Makhmudov Ramiz Ragipovich
|
RU2435774C1 |
| METHOD OF PRODUCING ETHYL 2-AMINO-2',5-DIOXO-5'-PHENYL-3-CYANO-1',2'-DIHYDRO-5H-SPIRO{INDENO[1,2-B]PYRAN-4,3'-PYRROLE}-4'-CARBOXYLATES |
2014 |
- Maslivets Andrej Nikolaevich
- Dmitriev Maksim Viktorovich
- Silajchev Pavel Sergeevich
- Makhmudov Ramiz Ragibovich
|
RU2569898C1 |
| METHYL 1-ARYL-3-HYDROXY-3'-METHYL-2,4,5'-TRIOXO-6-PHENYL-2,4,5,6-TETRAHYDRO-5'H-SPIRO[INDOLE-7,4'-ISOXAZOLE]-7a(1H)-CARBOXYLATES, METHYL 1-ARYL-(1'-PHENYL AND 1'-BENZYL)-3-HYDROXY-3'-METHYL-2,4,5'-TRIOXO-6-PHENYL-1',2,4,5,5',6-HEXAHYDROSPIRO[INDOLE-7,4'-PYRAZOLE]-7a(1H)-CARBOXYLATES AND METHYL 1'-ARYL-3'-HYDROXY-1,2',3,4'-TETRAOXO-6'-PHENYL-1,2',3,4',5',6'-HEXAHYDROSPIRO[INDENE-2,7'-INDOLE]-7a'(1'H)-CARBOXYLATES, DEMONSTRATING ANALGESIC ACTIVITY AND METHOD FOR OBTAINING THEREOF |
2014 |
- Silajchev Pavel Sergeevich
- Filimonov Valerij Olegovich
- Maslivets Andrej Nikolaevich
- Makhmudov Ramiz Ragibovich
|
RU2577528C2 |
| ETHYL 5-ALKYL-7,7-DIMETHYL-2',9,11-TRIOXO-5'-PHENYL-1',2',5,6,7,8,9,11-OCTAHYDROSPIRO{INDENO[1,2-b][QUIOLINE-10,3'-PYRROL}-4'-CARBOXYLATES AND METHOD FOR PREPARING THEM |
2012 |
- Dmitriev Maksim Viktorovich
- Silajchev Pavel Sergeevich
- Makhmudov Ramiz Ragibovich
- Maslivets Andrej Nikolaevich
|
RU2485120C1 |
| METHOD FOR PREPARATION OF ETHYL 3-(3-HYDROXY-1,4-DIOXO-1,4-DIHYDRONAPHTHALEN-2-YL)-2,5,10-TRIOXO-10b-PHENYL-1,2,3,5,10,10b -HEXAGYDRO-3aH-NAPHTO [2',3':4,5]FURO[3,2-b]PYRROL-3a-CARBOXYLATES |
2017 |
- Maslivets Andrej Nikolaevich
- Dmitriev Maksim Viktorovich
- Balandina Svetlana Yurevna
- Kamalova Aleksandra Renatovna
- Salnikova Tatyana Vladislavovna
|
RU2643372C1 |
| 2'-AMINO-2,5'-DIOXO-5-PHENYL-1,2,5',6',7',8'-HEXAHYDRO-1'H-SPIRO[PYRROL-3,4'-QUINOLINES] |
2020 |
- Maslivets Andrej Nikolaevich
- Dmitriev Maksim Viktorovich
- Balandina Svetlana Yurevna
- Sabitov Andrej Aleksandrovich
- Salnikova Tatyana Vladislavovna
|
RU2743922C1 |
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2013 |
- Stepanova Ekaterina Evgen'Evna
- Maslivets Andrej Nikolaevich
- Makhmudov Ramiz Ragibovich
|
RU2556998C2 |
| (Z)-1'-R-6',6'-DIMETHYL-3-(PHENYL(ARYLAMINO)METHYLENE)-6',7'-DIHYDRO-3H-SPIRO[FURANE-2,3'-INDOL]-2',4,4',5(1'H,5'H)TETRAONS AND METHOD OF THEIR OBTAINING |
2008 |
- Maslivets Andrej Nikolaevich
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- Aliev Zajnutdin Gasanovich
|
RU2365592C1 |
| INTERMEDIATE PRODUCTS - METHYL 7-ARYL-4, 9-DIAROYL-3-HYDROXY-1-(2-HYDROXYPHENYL)-2,6-DIOXO-1, 7-DIAZASPIRO[4,4]NONE-3, 8-DIENE-8-CARBOXYLATES; METHYL 6, 9-DIARYL-11-AROYL-2-(O-HYDROXYPHENYL)-3, 4,10-TRIOXO-7-OXA-2, 9-DIAZATRICYCLO[6.2.1.0]UNDEC-5-ENE-8-CARBOXYLATES; METHOD OF PRODUCING METHYL 6, 9-DIARYL-11-AROYL-2-(O-HYDROXYPHENYL)-3, 4, 10-TRIOXO-7-OXA-2, 9-DIAZATRICYCLO [6.2.1.0]UNDEC-5-ENE-8-CARBOXYLATES; METHYL 11-BENZOYL-2-O-HYDROXYPHEHYL-3, 4, 10-TRIOXO-9-P-TOLYL-6-PHENYL-7-OXA-2, 9-DIAZATRICYCLO [6.2.1.0]UNDEC-5-ENE-8-CARBOXYLATE HAVING ANTIMICROBIAL ACTIVITY |
2008 |
- Racheva Nadezhda L'Vovna
- Maslivets Andrej Nikolaevich
- Aleksandrova Galina Arsent'Evna
|
RU2383550C1 |
| METHOD FOR PRODUCING 4-AROYL-1-(2-HYDROXYARYL)-5-(1H-INDOL-3-YL)-1,3-DIHYDRO-2H-PYRROLE-2,3-DIONES WITH ANTIMICROBIAL ACTIVITY |
2023 |
- Maslivets Andrei Nikolaevich
- Balandina Svetlana Iurevna
- Kobelev Aleksandr Ivanovich
- Karavaev Danil Aleksandrovich
|
RU2806040C1 |
