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2 556 998

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IPC

C07D498/22(2006-01-01)

A61K31/5383(2006-01-01)

A61P29/00(2006-01-01)

(21) (22)

Application

2013125799/04, 2013-06-04

(24)

Start date

2013-06-04

(22)

Actual filing date

2013-06-04

(45)

Published

2015-07-20

(72)

Inventor

Stepanova Ekaterina Evgen'EvnaMaslivets Andrej NikolaevichMakhmudov Ramiz Ragibovich

(73)

Holder

Federal'Noe Gosudarstvennoe Bjudzhetnoe Obrazovatel'Noe Uchrezhdenie Vysshego Professional'Nogo Obrazovanija Gosudarstvennyj Natsional'Nyj Issledovatel'Skij Universitet"Obshchestvo S Ogranichennoj Otvetstvennost'Ju

9-ARYL-6,8,20-TRIOXA-13-AZAPENTACYCLO[11,8,0,01,10,02,7014,19]HENEICOSA-9,14,16,18-TETRAENE-11,12,21-TRIONES AND METHOD FOR PRODUCTION THEREOF Russian patent published in 2015 - IPC C07D498/22 A61K31/5383 A61P29/00

Abstract RU 2556998 C2

FIELD: chemistry.

SUBSTANCE: invention relates to a method of producing 9-aryl-6,8,20-trioxa-13-azapentacyclo-[11.8.0.0^1,10.0^2,7.0^14,19]heneicosa-9,14,16,18-tetraene-11,12,21-triones (IIa-d), which includes reacting 3-aroyl-1H-pyrrolo[2,1-c][1,4]benzoxazine-1,2,4-triones (Ia-d) with 3,4-dihydro-2H-pyran in a medium of an inert aprotic solvent, followed by separation of the end products. In general formula (I) Ar=Ph (a, d), C₆H₄Br-4 (b), C₆H₄OMe-4 (c), R=H (a-c), Cl (d).

EFFECT: obtaining 9-aryl-6,8,20-trioxa-13-azapentacyclo-[11,8,0,0^1,10,0^2,7,0^14,19]heneicosa-9,14,16,18-tetraene-11,12,21-triones.

2 cl, 1 tbl, 5 ex

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RU 2 556 998 C2

Authors

Stepanova Ekaterina Evgen'Evna

Maslivets Andrej Nikolaevich

Makhmudov Ramiz Ragibovich

Dates

2015-07-20—Published

2013-06-04—Filed