pH-MODULATED COMPOSITIONS FOR PULMONARY DELIVERY Russian patent published in 2017 - IPC A61K9/12 A61K9/72 A61K31/43 A61K31/545 A61K31/35 A61K31/496 A61K31/7048 A61K33/24 A61P31/00 A61P7/00 

FIELD: medicine.

SUBSTANCE: invention relates to aerosol composition for delivery into patient's airway by inhalation, consisting of particles with aerodynamic diameter of 2.0-12.0 micron and combined total volume of 0.1–3.0 ml, wherein composition contains ciprofloxacin, pharmaceutically acceptable carrier and agent, affecting pH, which increases solubility of medicinal agent in carrier and is present in molarity, required to vary composition pH from 7.4 by at least 3.0 logarithmic units and no more than 5.4 logarithmic units; where agent, affecting pH, is acetic acid or its pharmaceutically acceptable salt, wherein said composition is characterized by low buffer capacity, such that, when it is in contact with fluid in human respiratory tract during certain period of time and under conditions of medium of human lungs, composition pH approaches pH 7.4 by 3.0 logarithmic units relative to composition pH before its introduction, besides, said composition is characterized by fact, that antibiotic in human lung acquires lower solubility as compared to its solubility in composition before its introduction.

EFFECT: composition has low buffer capacity, which enables to change quickly pH of composition and provide formation of crystals, which slow down release of antibiotic in order to increase efficiency of treating infection.

1 cl, 2 ex