ANTIGEN-BINDING PROTEINS Russian patent published in 2017 - IPC C07K16/46 C12N15/13 C12N15/63 C12N5/10 

FIELD: medicine.

SUBSTANCE: invention relates to immunology. Method of producing antigen-binding protein and host cell for its production are proposed. Antigen-binding protein obtained using present invention includes: a) two modified heavy chains of antibody, in which VH of each heavy chain has been replaced for VL of said antibody and which are linked to each other via their CH3-domains of Fc-part; and b) two modified heavy chains of antibody, in which CH1 of each heavy chain has been replaced for CL of above antibody and which are linked to each other via their CH3-domains of Fc-part; wherein VL-domains of heavy chains a) are linked to VH domains of heavy chains b), and CH1-domains of heavy chains a) are linked to CL-domains of heavy chains b).

EFFECT: obtained antigen-binding protein shows increased antibody-dependent cell mediated cytotoxicity (ADCC).

14 cl, 12 dwg, 5 tbl, 10 ex