FIELD: medicine.
SUBSTANCE: invention relates to medicine, dentistry, molecular biology and clinical-laboratory diagnostics. Described is a method of determining intensity of suppuration (pyorrhoea) of periodontal tissues. Method is based on measuring in scrapes from periodontium level interleukin-8 (IL-8) gene RNA relative to representation of reference RNA or DNA. Obtained parameters are used to calculate ratio of levels for each specific sample. Value of obtained parameter is interpreted as a marker of suppuration. Invention can be used to determine pyorrhoea in individual patients with aggressive and chronic paradontium, including after loss of tooth, in cases when intensity of said process does not allow visual detection of pus, as well as in tissues in contact with implants and other orthodontic structures.
EFFECT: method provides highly sensitive and objective quantitative characteristic of degree of suppuration of analysed area of periodontium, which enables to evaluate risk of acute local inflammation and periodontium destruction in future, establish implants and other dental structures, evaluate effectiveness of therapeutic measures.
3 cl, 4 tbl
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