FIELD: biotechnology.
SUBSTANCE: invention relates to biotechnology, namely to obtaining cell lines used for development of treating with target preparations, and can be used in medicine. Cell line crov Cel of human mucinous ovarian carcinoma is characterized by presence in exon 9 of gene PIK3CA of somatic missense mutation E542K (1624 G/A), leading to amino acid replacement in 542 codon (p.Glu542Lys). Mutation is registered in international database (COSMIC, COSM760Id) and is associated with higher sensitivity to mTOR inhibitor therapy. Obtained cell line is stored in Russian national collection of industrial microorganisms FGUPGosNIIGenetika under No. 160.
EFFECT: invention enables to obtain cell line crov Cel of human mucinous ovarian carcinoma, which has stable culture and morphological characteristics.
1 cl, 8 dwg, 3 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR EARLY DIAGNOSIS OF NEOPLASTIC TRANSFORMATION OF ENDOMETRIOID OVARIAN CYSTS | 2020 |
|
RU2730952C1 |
| SUBDERMAL XENOGRAFTS OF CELL LINE OF AMELANOTIC HUMAN SKIN MELANOMA MEL RAC WITH MUTATION NRAS FOR PRECLINICAL STUDY OF ANTINEOPLASTIC TARGETED AGENTS | 2016 |
|
RU2651939C2 |
| BIOMARKERS | 2005 |
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| BIOMARKER | 2005 |
|
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| METHOD FOR MODELING OVARIAN CANCER EXPERIMENTALLY IN RATS | 2020 |
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| METHOD FOR PREDICTION OF THE PATHOLOGICAL PROCESS IN UTERINE BODY CANCER | 2019 |
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| METHOD FOR TREATING ONCOLOGICAL DISEASES | 2006 |
|
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| METHOD FOR EARLY DIAGNOSTICS OF SEROUS OVARIAN CARCINOMA OF HIGH MALIGNANCY DEGREE BASED ON CHANGE CELLULAR COMPOSITION OF FALLOPIAN TUBE EPITHELIUM | 2016 |
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RU2641094C1 |
| METHOD OF DIFFERENTIAL DIAGNOSTICS OF TYPE OF STOMACH CANCER BY IMMUNOHISTOCHEMICAL TESTING METHOD | 2023 |
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RU2813670C1 |
| METHOD OF PRODUCTION OF SUBDERMAL XENOGRAFTS OF CELL LINE OF PEOPLE SKIN MELANOMA mel Cher WITH MUTATION V600E BRAF FOR PRECLINICAL STUDY OF ANTINEOPLASTIC TARGETED AGENTS | 2014 |
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RU2572569C1 |
