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2 743 219

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IPC

G09B23/28(2006-01-01)

(21) (22)

Application

2020131311, 2020-09-22

(24)

Start date

2020-09-22

(22)

Actual filing date

2020-09-22

(45)

Published

2021-02-16

(72)

Inventor

Murazov Yaroslav GennadevichSemenov Aleksandr LeonidovichArtemeva Anna SergeevnaNyuganen Anna AndreevnaMurashkina Anna AndreevnaBelyaev Aleksej MikhajlovichStukov Aleksandr Nikolaevich

(73)

Holder

Federalnoe Gosudarstvennoe Byudzhetnoe Uchrezhdenie Meditsinskij Issledovatelskij Tsentr Onkologii Imeni N.N. Petrova" Ministerstva Zdravookhraneniya Rossijskoj Federatsii

METHOD FOR MODELING OVARIAN CANCER EXPERIMENTALLY IN RATS Russian patent published in 2021 - IPC G09B23/28

Abstract RU 2743219 C1

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to experimental oncology, pharmacology, and can be used to model ovarian cancer experimentally in rats. A method of modeling ovarian cancer experimentally in rats by orthotopic transplantation of a tumor cell culture involves sexually mature female Wistar rats are injected once under the membrane of the bag of both ovaries with 25 mcl of ascitic syngeneic ovarian carcinoma containing 4.4±0.4×10⁶ (mean±SD) of tumor cells obtained from Wistar female rats, on which the strain is maintained by permanent intraperitoneal passages of ascites containing 1×10⁷ cells in 0.5 ml of physiological solution in rat.

EFFECT: method enables to reproduce late stages (III-IV stages) of ovarian cancer experimentally in rats with high probability (100%), reduces expenses for experiment, has accessibility.

1 cl, 2 ex, 17 dwg

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RU 2 743 219 C1

Authors

Murazov Yaroslav Gennadevich

Semenov Aleksandr Leonidovich

Artemeva Anna Sergeevna

Nyuganen Anna Andreevna

Murashkina Anna Andreevna

Belyaev Aleksej Mikhajlovich

Stukov Aleksandr Nikolaevich

Dates

2021-02-16—Published

2020-09-22—Filed