FIELD: biotechnology.
SUBSTANCE: present invention relates to biotechnology. Disclosed are immunogenic compositions in form of a multilayer film, containing B-cell (antibody) epitope of RSV-G169-191 and additionally T-cell epitope of RSV-M281-95 proteins of respiratory syncytial virus (RSV), wherein epitope of RSV-G is located in outer layer of film. Said film comprises two or more layers of polyelectrolytes, where adjacent layers contain oppositely charged polyelectrolytes, containing polycationic substance or polyanionic substance, having molecular weight greater than 1,000, and at least 5 charges per molecule. In addition, described is a method for immunisation against RSV.
EFFECT: compositions according to present invention provide increased B-cell response against RSV and can be used in preventing RSV infection.
17 cl, 21 dwg, 5 tbl, 19 ex
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