FIELD: biotechnology.
SUBSTANCE: present invention relates to biotechnology. Disclosed are immunogenic compositions in form of a multilayer film, containing B-cell (antibody) epitope of RSV-G169-191 and additionally T-cell epitope of RSV-M281-95 proteins of respiratory syncytial virus (RSV), wherein epitope of RSV-G is located in outer layer of film. Said film comprises two or more layers of polyelectrolytes, where adjacent layers contain oppositely charged polyelectrolytes, containing polycationic substance or polyanionic substance, having molecular weight greater than 1,000, and at least 5 charges per molecule. In addition, described is a method for immunisation against RSV.
EFFECT: compositions according to present invention provide increased B-cell response against RSV and can be used in preventing RSV infection.
17 cl, 21 dwg, 5 tbl, 19 ex
| Title |
Year |
Author |
Number |
| ANTIGENIC POLYPEPTIDES BASED ON THE RESPIRATORY SYNCYTIAL VIRUS SEQUENCE |
2019 |
- Nejbel, Gari Dzh.
- Vej, Chikh-Dzhen
- Svenson, Kurt
- Dkhal, Pradip
- Dkharanipragada, Ram
- Besev, Magnus
|
RU2807992C2 |
| IMMUNOGENS FOR VACCINATION AGAINST HIV |
2013 |
- Brande Kristian
- Mote Pukhadas Beatris
- Lyano Anuska
|
RU2648791C2 |
| IMMUNOGENIC COMPOSITIONS AND METHODS |
2008 |
- Fisher Dzherald V.
- Daum Ljuk T.
|
RU2468034C2 |
| MODIFIED SV F PROTEINS OF SV AND METHODS OF USING THEM |
2009 |
- Pushko,Piter
- U,Injun'
- Massar,Majkl
- Lju,E
- Smit,Gejl
- Chzhou,Bin'
|
RU2531510C2 |
| VACCINE COMPOSITION FOR CONTROLLING INFESTATION WITH ECTOPARASITES |
2011 |
- Rodriges Malon Alina
- Fernandes Dias Erlinda
- Estrada Garsiya Mario Pablo
- Sarpio Gosales Yamila
|
RU2585226C2 |
| DNA COMPOSITION FOR INDUCING IMMUNE RESPONSE ON TUMOUR-ASSOCIATED MACROPHAGUES |
2007 |
- Rejsfeld Ral'F A.
- Sjan Zhun
- Lo Jun'Pin
|
RU2459631C2 |
| METHOD FOR TREATING AUTOIMMUNE DISEASE USING BIOCOMPATIBLE BIOABSORBABLE NANOSPHERE |
2011 |
|
RU2635537C2 |
| ANTIGEN TAU-PEPTIDES AND THEIR APPLICATION |
2010 |
- Smith Iii George Joseph
- Wills Kenneth Nelson
- Zhu Jeff Xianchao
|
RU2518291C2 |
| RECOVERED PEPTIDE EXHIBITING SPECIFIC ANTI-GDF-8 ANTIBODY BINDING ACTIVITY, RECOVERED NUCLEIC ACID MOLECULE, EXPRESSION VECTOR, HOST CELL, METHOD FOR PRODUCING PEPTIDE, VACCINE COMPOSITION AND METHOD OF ELICITING ANTI-GDF-8 IMMUNE RESPONSE, METHOD OF ANTI-GDF-8 ANTIBODY SELECTION SCREENING AND METHOD OF GDF-8 ACTIVITY DOWN-REGULATION IN ANIMAL |
2004 |
- Dzhanker Dehvid Eh.
- Kokhrehn Mark D.
|
RU2422460C2 |
| IMMUNOGENS FOR VACCINATION AGAINST HIV |
2013 |
- Brander, Christian
- Mothe Pujadas, Beatriz
- Llano, Anuska
|
RU2721274C2 |
