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(19)

RU

(11)

2 610 661

(13)

C2

(51)

IPC

C12N15/113(2010-01-01)

A61K31/7088(2006-01-01)

A61K48/00(2006-01-01)

C12N15/63(2006-01-01)

(21) (22)

Application

2012142242, 2011-04-08

(24)

Start date

2011-04-08

(22)

Actual filing date

2011-04-08

(45)

Published

2017-02-14

(72)

Inventor

Kollard DzhozefKhorkova Sherman Olga

(73)

Holder

Kurna, Ink.

TREATMENT OF FIBROBLAST GROWTH FACTOR 21 (FGF21) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO FGF21 Russian patent published in 2017 - IPC C12N15/113 A61K31/7088 A61K48/00 C12N15/63 

Abstract RU 2610661 C2

FIELD: biotechnology.

SUBSTANCE: described oligonucleotides, that increase expression of a gene of fibroblast growth factor 21 (FGF21), by interaction with the natural targeting antisense polynucleotides fibroblast growth factor 21 (FGF21). The present invention also relates to the use of the described oligonucleotides for the treatment of diseases and disorders associated with the expression of FGF21.

EFFECT: invention expands the arsenal of tools aimed for the treatment of diseases and disorders associated with the expression of FGF21.

26 cl, 2 dwg, 3 ex, 1 tbl

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RU 2 610 661 C2

Authors

Kollard Dzhozef

Khorkova Sherman Olga

Dates

2017-02-14—Published

2011-04-08—Filed

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