FIELD: medicine.
SUBSTANCE: invention relates to an antisense oligonucleotide, representing a phosphorothioate analogue with length of 19 to 30 nucleotides, which is a compound which hybridises with natural antisense polynucleotide gene atonal homolog 1 (ATON1) and increases expression of said gene ATON1 in vivo or in vitro as compared with normal control. Said oligonucleotide has at least 50% sequence identity with sequence of 19-30 nucleic acids of RNA molecule transcribed from polynucleotide ATON1. Invention also relates to use of said oligonucleotides for treatment of diseases and disorders associated with expression of gene ATON1.
EFFECT: invention widens range of tools aimed at treatment of diseases and disorders associated with expression of gene ATON1.
26 cl, 1 dwg, 1 tbl, 2 ex
| Title |
Year |
Author |
Number |
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2011 |
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| TREATMENT OF SODIUM CHANNEL, VOLTAGE-GATED, ALPHA SUBUNIT (SCNA) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO SCNA |
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|
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| TREATMENT OF DISEASES ASSOCIATED WITH FRATAXIN (FXN), BY INHIBITING NATURAL ANTISENSE FXN TRANSCRIPT |
2012 |
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| TREATING DISEASES, ASSOCIATED WITH NANOG, BY INHIBITION OF NATURAL ANTISENSE NANOG TRANSCRIPT |
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|
RU2608493C2 |
| TREATMENT OF DISEASES ASSOCIATED WITH SUBSTRATE OF INSULIN RECEPTOR 2 (IRS2) BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO IRS2 |
2010 |
- Kollard Dzhozef
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|
RU2616283C2 |
