IMMUNE DYSFUNCTION ASSESSMENT METHOD FOR PRESCHOOL CHILDREN WITH RECURRENT RESPIRATORY INFECTION, RESIDING NEAR CHEMICALLY HAZARDOS PRODUCTION Russian patent published in 2017 - IPC G01N33/53 

FIELD: medicine.

SUBSTANCE: to assess the immunity dysfunction for preschool children with recurrent respiratory infection, living in areas near the chemically hazardous industries, samples of peripheral blood are selected, and allelic versions A₁A₁ and A₁A₂ of TNFα cytokine gene and its quantitative content, as well as indicators of IL-10, IFNγ and IgA cytokine quantitative content are determined in lymphocytes by polymerase chain reaction. When the allelic version is A₁A₁, TNFα contentα is more than 30 pg/ml IL-10 is less than 20 pg/ml, IFNγ is less than 12 pg/ml, IgA is less than 1 g/l, immunity dysfunction against recurrent respiratory infection is predicted. When the allelic version is A₁A₂, TNFα contentα is less than 40 pg/ml IL-10 is more than 26 pg/ml, IFNγ is more than 40 pg/ml, IgA is more than 1.5 g/l, good recurrent respiratory infection flow without immune dysfunction development is predicted.

EFFECT: application of this method allows immunological monitoring of children with different clinical forms of recurrent respiratory infection under the conditions of anthropogenic load.

1 dwg, 1 tbl, 2 ex