METHOD FOR DIAGNOSING CHRONIC LYMPHOPROLIFERATIVE DISEASES OF THE NASOPHARYNX IN CHILDREN ASSOCIATED WITH THE COMBINED EFFECT OF ATMOSPHERIC CHEMICAL FACTORS AND PERSISTENT HERPES VIRUS INFECTION Russian patent published in 2022 - IPC A61B5/353 A61B5/87 A61B8/08 G01N33/49 G01N33/68 G01N33/72 G01N33/84 G01N33/569 G01N33/573 

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to clinical laboratory diagnostics, ecology, and can be used to diagnose chronic lymphoproliferative diseases of the nasopharynx in children associated with the combined effect of atmospheric chemical factors and persistent herpes virus infection. A blood sample is taken from a child with a history of a diagnosis of persistent herpes virus infection. The content of benzene, xylene, formaldehyde, manganese and chromium is determined in the blood sample. The child's functional and laboratory parameters are determined, which act as diagnostic markers. As functional indicators, the following are determined: by the method for cardiointervalography, the indicator of variational pulsometry (Mo), by the method for rhinomanometry, the total volumetric flow (TVF), which characterizes the degree of severity of nasal breathing disorders, by the method for ultrasound examination, the structural parameters of the palatine tonsils; reactive hyperplasia of the lymph nodes of the upper jugular group and mesenteric lymph nodes and the structure and size of the liver. As laboratory indicators, the following are determined: the level of monocytes, the content of total and direct bilirubin, the level of creatine phosphokinase (CPK) and immunological parameters: absolute phagocytosis, the content of interleukin 4 (IL-4), the content of interleukin 10 (IL-10), the level of immunoglobulin E (IgE) general, the level of IgE specific to formaldehyde, manganese and IgE specific to benzene. If there are antibodies to herpes infection in the blood and if the content of benzene, xylene, formaldehyde, manganese and chromium in the blood exceeds the reference amount by at least 1.3 times, in the presence of a combination of the following indicators: Mo level within 0.705- 0.860 sec, severe nasal obstruction with TVF less than 500 cm³/s, the presence of structural changes in the palatine tonsils, the presence of reactive hyperplasia of the lymph nodes of the upper jugular group and lymph nodes of the mesenteric zone, an increase in the size of the liver in the form of an oblique vertical size of the left lobe of the liver of 44.0 mm or more, and/or the presence of reactive changes in its structure; with a blood content of monocytes within 7.15-7.71%, with a total bilirubin level of 23.15-27.73 mcmol/dm³, with a direct bilirubin content in the range of 5.50-6.08 mcmol/dm³, with CPK content within 139.18-191.46 U/dm³, with absolute phagocytosis content within 2.07⋅10⁹/dm³ - 2.41⋅10⁹/dm³, with IL-4 content within 2.409-3.245 pg/cm³ , IL-10 in the range of 4.722-8.372 pg/cm³, with a total IgE level in the range of 124.66-205.18 IU/cm³ and in the presence of IgE specific to formaldehyde, manganese and IgG specific to benzene in the blood, chronic lymphoproliferative diseases of the nasopharynx associated with the combined effect of atmospheric chemical factors and persistent herpes virus infection.

EFFECT: method enables informative and evidence-based diagnostics in children of chronic lymphoproliferative diseases of the nasopharynx associated with the combined effect of atmospheric chemical factors and persistent herpes virus infection, due to a complex of functional and laboratory diagnostic factors.

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