FIELD: medicine, pharmaceutics.
SUBSTANCE: group of inventions relates to field of creating preparation possessing neuroprotective properties in experiment, including biodegradable polymer matrix based on silk fibroin with immobilised peptide-agonist of PAR 1 receptor, released by activated protein C in ratio 99-99.9:0.1-1 wt % fibroin:peptide, as well as method for obtaining thereof.
EFFECT: application of the claimed group of inventions makes it possible to protect peptide -agonist of PAR 1 receptor, released by activated protein C from proteolysis and regulate rate of preparation output under conditions of experiment.
4 cl, 6 dwg, 1 tbl, 3 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR NEUROPROTECTION IN EXPERIMENT | 2015 |
|
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| METHOD FOR ASSESSING COMPLEX PROTECTION OF CELLS UNDER NEURO-INFLAMMATORY ON IN VITRO MODELS UNDER EXPOSURE TO PAR1 AGONIST | 2022 |
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| METHOD FOR DETERMINING FUNCTIONAL ACTIVITY PROFILE OF RECEPTOR PEPTIDES-AGONISTS ACTIVATED BY PROTEASE TYPE 1 UNDER EXPERIMENTAL CONDITIONS IMITATING ISCHEMIC | 2020 |
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| BIORESORBABLE MICRO-CARRIER FOR CELL DELIVERY TO REGION OF WOUND HEALING AND REGENERATION | 2015 |
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|
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| METHOD OF SKIN RECOVERY | 2016 |
|
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| AGENT FOR ANTIPLATELET, ANTI-INFLAMMATORY AND CYTOPROTECTIVE THERAPY | 2012 |
|
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| METHOD FOR PREPARING BIODEGRADED COMPOSITE MATRIX OF REGENERATED SILK FIBROIN Bombyx mori AND ITS USE | 2012 |
|
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| FUNCTIONALLY ACTIVE BIODEGRADABLE VASCULAR PATCH FOR ARTERIAL RECONSTRUCTION | 2019 |
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| METHOD FOR PRODUCING MINERALIZED COMPOSITE MICROSCAFFOLDS FOR BONE TISSUE REGENERATION | 2016 |
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RU2660558C2 |
