FIELD: pharmaceutics.
SUBSTANCE: invention relates to pharmaceutical composition in single dosage form in form of nasal spray for treating upper airway diseases. Pharmaceutical composition contains corticosteroid for local application and quinolone or fusidic acid, wherein weight ratio of corticosteroid for local application to quinolone or fusidic acid ranges from 0.02 to 20, and amount of quinolone or fusidic acid is less than 1 mg. Preferably composition can be used for treating acute or chronic sinusitis and nasal polyp. Invention also relates to pharmaceutical preparation in form of nasal spray containing several single doses; dosage form of pharmaceutical composition containing from 50 to 300 mcg of corticosteroid for local application and from 150 to 400 mcg of quinolone; use of composition for treating upper airway diseases.
EFFECT: pharmaceutical composition under invention provides higher clinical effectiveness, reduced toxicity and minimization of used amount of active substances.
19 cl, 2 ex
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