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2 614 945

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(51)

IPC

C07D307/94(2006-01-01)

(21) (22)

Application

2015127170, 2015-07-06

(24)

Start date

2015-07-06

(22)

Actual filing date

2015-07-06

(45)

Published

2017-03-31

(72)

Inventor

Khafizova Lejla OsmanovnaShajbakova Mariya GennadevnaChobanov Nuri MamedeevichDzhemilev Usein Memetovich

(73)

Holder

Federalnoe Gosudarstvennoe Byudzhetnoe Uchrezhdenie Nauki Institut Neftekhimii I Kataliza Rossijskoj Akademii Nauk

METHOD FOR PRAPARING 1-PHENYL-4-OXASPIRO[2,4]HEPTANE Russian patent published in 2017 - IPC C07D307/94

Abstract RU 2614945 C2

FIELD: pharmacology.

SUBSTANCE: invention relates to the method for preparing 1-phenyl-4-oxaspiro[2.4]heptane (1), characterized in that styrol is reacted with γbutyrolactone and aluminium chloride (AlCl₃), magnesium (Mg, powder) and catalyst Cp₂ZrCl₂ in a molar ratio of styrol: γ-butyrolactone:AlCl₃:Mg:Cp₂ZrCl₂=10:15:(20-30):(10-14):(1.8-2.2), in tetrahydrofuran in the argon atmosphere at 20-22°C and under the atmospheric pressure for 6-10 hours. The yield of 1-phenyl-4-oxaspiro[2.4] heptane (1) is 78-92%.

EFFECT: compound is of interest as a source of synthons for creating biologically active compounds for the medical and agricultural purposes, which can be used for the medicine synthesis, which exhibit antibacterial, antiviral, antiinflammatory, antifungal, analgesic properties.

1 tbl, 1 ex

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RU 2 614 945 C2

Authors

Khafizova Lejla Osmanovna

Shajbakova Mariya Gennadevna

Chobanov Nuri Mamedeevich

Dzhemilev Usein Memetovich

Dates

2017-03-31—Published

2015-07-06—Filed