RECOMBINANT DNA FRAGMENT, ENCODING HUMAN ALPHA-FETOPROTEIN (AFP), CONTAINING "SLOW" LEUCINE-ENCODING CODONS, EXPRESSION PLASMID, CONTAINING SAID FRAGMENT, SACCHAROMYCES CEREVISIAE CELL, TRANSFORMED WITH SAID PLASMID, AND METHOD FOR OBTAINING HUMAN AFP Russian patent published in 2017 - IPC C12N15/12 C12N15/81 C12N1/19 C12P21/02 C12R1/865 

Abstract RU 2617943 C2

FIELD: medicine.

SUBSTANCE: invention relates to field of biotechnology, can be used for obtaining human alpha-fetoprotein (AFP) with application of strains of Saccharomyces cerevisiae yeasts, containing recombinant AFP gene. Obtained are: recombinant human AFT, containing so-called "slow" codons, encoding leucine in conservative AFP sections, recombinant plasmid and Saccharomyces cerevisiae cell for expression and secretion of said recombinant AFP respectively.

EFFECT: invention makes it possible to increase production of active AFP.

9 cl, 16 dwg, 3 tbl, 6 ex

Similar patents RU2617943C2

Title Year Author Number
STRAIN PICHIA PASTORIS Y-4349 - PRODUCER OF HUMAN ALPHA-FETOPROTEIN, METHOD OF PRODUCING ALPHA-FETOPROTEIN AND COMPOSITION CONTAINING IT 2024
  • Cheveleva Anna Nikolaevna
  • Bydanov Dmitrii Aleksandrovich
  • Vostrov Ivan Aleksandrovich
  • Galantsev Aleksandr Vladimirovich
  • Kruglyi Boris Igorevich
  • Akopian Iurii Vagenakovich
  • Bashmakov Vladimir Iurevich
RU2838856C1
RECOMBINANT PLASMID DNA pPDGFB ENCODING A POLYPEPTIDE WITH HUMAN PLATELET-BB GROWTH FACTOR HUMAN PROPERTIES, AND A RECOMBINANT STRAIN OF METHYLOTROPHIC YEAST PICHIA PASTORIS, A PRODUCER OF A POLYPEPTIDE WITH HUMAN PLATELET-BB GROWTH FACTOR HUMAN PROPERTIES 2017
  • Gerasimov Andrej Sergeevich
  • Litvinets Sergej Gennadevich
RU2668828C1
STRAIN OF YEAST SACCHAROMYCES CEREVISIAE CONTAINING RECOMBINANT PLASMID YEP 63/AB, - A PRODUCER OF HUMAN HEPATITIS B VIRUS M-PROTEIN DERIVATIVE 1994
  • Biragijn Ar'Jaa[Mn]
  • Skrjabin Konstantin Georgievich[Ru]
  • Ehl'Darov Mikhail Anatol'Evich[Ru]
RU2082759C1
RECOMBINANT PLASMID DNA pPBS-St9 CODING SOMATOTROPIN POLYPEPTIDE, AND SACCHAROMYCES CEREVISIAE YEAST STRAIN FOR PRODUCING RECOMBINANT SOMATOTROPIN 2011
  • Startsev Veniamin Aleksandrovich
  • Startsev Innokentij Aleksandrovich
  • Startseva Julija Vladimirovna
  • Sopova Julija Viktorovna
  • Zadorskij Sergej Pavlovich
RU2465315C1
CARTRIDGE AND RECOMBINANT PLASMID FOR EXPRESSION AND SECRETION OF HUMAN MECHANODEPENDENT GROWTH FACTOR (MGF), STRAIN SACCHAROMYCES CEREVISIAE - MGF PRODUCER AND METHOD OF MGF PRODUCTION 2006
  • Keruchen'Ko Jan Stanislavovich
  • Khotchenkov Vjacheslav Petrovich
  • Popov Vladimir Olegovich
  • Morozkina Elena Vladimirovna
  • Marchenko Aleksej Nikolaevich
  • Benevolenskij Sergej Vladimirovich
RU2344173C2
HYBRID PROTEIN HAVING PROLONGED ACTION, BASED ON RECOMBINANT HUMAN INTERFERON ALPHA-2 (VARIANTS), METHOD OF ITS PRODUCTION AND STRAIN OF Saccharomyces cerevisiae FOR IMPLEMENTING THIS METHOD (VERSIONS) 2013
  • Kozlov Dmitrij Georgievich
  • Cheperegin Sergej Ehduardovich
  • Gubajdullin Irek Il'Jasovich
  • Efremov Boris Dmitrievich
  • Kotlova Elena Konstantinovna
  • Rjabichenko Viktor Vasil'Evich
  • Chestukhina Galina Georgievna
  • Jarotskij Sergej Viktorovich
RU2515913C1
RECOMBINANT PLASMID PFS 19 DETERMINING SYNTHESIS OF THE SURFACE ANTIGEN S OF HUMAN VIRUS HEPATITIS B 1992
  • Sasnauskas Kjastutis Vlado
  • Iomantene Rasa Jono
  • Janulajtis Arvidas Andrjaus
  • Bumjalis Vladas Vlado
  • Vetrinas Aurimas Juozo
RU2115730C1
RECOMBINANT PLASMID DNA DETERMINING SYNTHESIS OF HUMAN FIBROBLAST INTERFERON IN YEAST CELLS, METHOD OF ITS CONSTRUCTION AND YEAST STRAIN SACCHAROMYCES CEREVISIAE AS PRODUCER OF HUMAN FIBROBLAST INTERFERON 1998
  • Padkina M.V.
  • Parfenova L.V.
  • Sambuk E.V.
  • Smirnov M.N.
RU2180003C2
METHOD OF MICROBIOLOGICAL SYNTHESIS OF MATURE HUMAN INTERFERON ALPHA-2, Saccharomyces cerevisiae STRAIN - MATURE HUMAN INTERFERON ALPHA-2 PRODUCER (VERSIONS) 2010
  • Kozlov Dmitrij Georgievich
  • Cheperegin Sergej Ehduardovich
  • Gubajdullin Irek Il'Jasovich
  • Efremov Boris Dmitrievich
  • Kazachenko Konstantin Jur'Evich
  • Jakovenko Andrej Romanovich
  • Kazarov Aleksandr Aleksandrovich
  • Kotlova Elena Konstantinovna
  • Rjabichenko Viktor Vasil'Evich
  • Chestukhina Galina Georgievna
  • Glazunov Aleksandr Viktorovich
  • Chernomorova Natal'Ja Olegovna
  • Akishina Raisa Illarionovna
RU2427645C1
STRAIN YEAST PICHIA PASTORIS PS107(pPIC9HAbIL-2) AS PRODUCER OF HYBRID PROTEIN CONSISTING OF HUMAN PLASMA BLOOD ALBUMIN AND HUMAN INTERLEUKIN-2, RECOMBINANT PLASMID pPIC9HAbIL-2 AND METHOD FOR ITS CONSTRUCTING 2006
  • Padkina Marina Vladimirovna
  • Zinov'Eva Julija Grigor'Evna
  • Sambuk Elena Viktorovna
  • Smirnov Mikhail Nikolaevich
RU2315105C1

RU 2 617 943 C2

Authors

Benevolenskij Sergej Vladimirovich

Vavilova Ekaterina Aleksandrovna

Dudich Igor Vyacheslavovich

Zatsepin Sergej Sergeevich

Morozkina Elena Vladimirovna

Semenkova Lidiya Nikolaevna

Ostroumov Yurij Igorevich

Dates

2017-04-28Published

2015-07-17Filed