METHOD OF PREDICTING THE FORMATION OF TOLERANCE AT ALLERGY TO THE CELL MILK PROTEIN IN CHILDREN OF EARLY AGE Russian patent published in 2017 - IPC G01N33/53 

FIELD: medicine.

SUBSTANCE: method involves the determination of serum sIgG4 concentration, as well as the additional determination of serum sIgE concentration in the protein components of cow milk by indirect immunofluorescence, prior to the appointment of an elimination diet. With the exponents sIgE≤0.7 and sIgG4 3+, sIgE>0.7 and sIgG4 3+, a favorable outcome of tolerance formation is 90.1-97.9%, and with a predictive probability of tolerance formation and no response, diagnostic administration of the product can be carried out after 6 months of elimination diet, and for the exponents sIgE≤0.7 and sIgG4 0-2+, sIgE>0.7 and sIgG4 0-2+, the favorable outcome of tolerance formation is from 0 to 19.2%, and with a predictive probability of no response, diagnostic injection of the product can be carried out not earlier than 12 months from the beginning of the elimination diet.

EFFECT: use of the proposed method allows to determine the optimal duration of the elimination diet and reduce the risk of exacerbations in the diagnostic administration of the product, which will greatly facilitate the management of patients with food allergies and will allow to determine in a timely manner the possibility of expanding the ration of the child and thereby reduce the costs of diagnostic and therapeutic-prophylactic measures.

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