KALMANGAFODIPIR, NEW CHEMICAL COMPOUND AND OTHER MIXED COMPLEX COMPOUNDS WITH METALS, METHODS FOR PREPARATION, COMPOSITIONS AND TREATMENT METHODS Russian patent published in 2017 - IPC C07F19/00 A61K31/555 A61P35/00 

FIELD: chemistry.

SUBSTANCE: invention relates to a mixed complex metal compound containing calcium and manganese in the form of a complex with a formula I compound or a pharmaceutically acceptable salt thereof: formula I. In formula I the radicals have the following meanings: X is CH, each R¹ independently represents -CH₂COR⁵, R⁵ represents hydroxy, each R² independently represents ZYR⁶, where Z represents C_1-3alkylene group, Y represents a bond, R⁶ represents OR⁸ or OP(O)(OR⁸)R⁷, R⁷ represents hydroxy or an unsubstitutedC_1-6alkyl or aminoalkyl group, R⁸ represents a hydrogen atom or a C_1-6alkyl group, R³ represents an ethylene group, and each R⁴ independently represents hydrogen or C_1-3alkyl. A pharmaceutical composition, a method of a mixed complex metal compound and a treatment method are also proposed.

EFFECT: improved treatment of pathological conditions caused by the presence of free radicals generated by oxygen.

26 cl, 35 dwg, 11 ex