COMPOUNDS FOR TREATING CANCER Russian patent published in 2013 - IPC C07D401/12 A61K31/44 A61P35/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to a method of treating cancer in a patient, wherein the method involves administering a cancer-inhibiting amount of a compound of formula I into a patient's body. The method of treating cancer in the patient, including a human, wherein the method involves administering the cancer-inhibiting amount of a first compound of formula I or a physiologically acceptable salt thereof into the patient's body, wherein X represents CH or N, each R¹ independently represents hydrogen or -CH₂COR⁵; R⁵ represents hydroxy, optionally hydroxylated alkoxy, amino or alkylamino; each R² independently represents the group ZYR⁶; Z represents a bond or the C_1-3 alkylene or oxoalkylene group optionally substituted by the group R⁷; Y represents a bond, an oxygen atom or the group NR⁶; R⁶ is a hydrogen atom, the group COOR⁸, the alkyl, alkenyl, cycloalkyl, aryl or aralalkyl group optionally substituted by one or more groups COOR⁸, CONR⁸ ₂, NR⁸ ₂, OR⁸, =NR⁸, =O, OP(O)(OR⁸)R⁷ and OSO₃M; R⁷ is hydroxy, the optionally alkoxylated or aminoalkyl group; R⁸ is a hydrogen atom or the optionally hydroxylated, optionally alkoxylated alkyl group; M is a hydrogen atom or one equivalent of a physiologically acceptable cation; R³ represents the C_1-8 alkylene group, 1,2-cycloalkylene group or 1,2-arylene group, optionally substituted by R⁷; and each R⁴ independently represents hydrogen or C_1-3 alkyl.

EFFECT: invention refers to a pharmaceutical composition for treating cancer in the patient, containing the compound of formula I, as well as to a kit for treating cancer.

23 cl, 3 ex, 7 dwg