KALMANGAFODIPIR, NEW CHEMICAL COMPOUND, AND OTHER MIXED COMPLEX COMPOUNDS WITH METALS, METHODS FOR PRODUCTION, COMPOSITIONS AND METHODS FOR TREATMENT Russian patent published in 2022 - IPC C07F19/00 C07F3/04 C07F13/00 A61K31/555 A61P35/00 A61P43/00 

FIELD: pharmaceuticals.

SUBSTANCE: invention relates to a pharmaceutical composition for treating a pathological condition in a patient, caused by the presence of free radicals formed from oxygen. The pharmaceutical composition is formed by combining a mixed complex compound with metals of a compound by the formula I or a salt thereof, with one or more physiologically acceptable excipients, wherein at least one excipient is selected from a group consisting of stabilisers, antioxidants, osmolality regulation agents, buffers, pH regulation agents, binding agents and fillers, wherein the mixed metals include calcium and manganese. In the formula I: X represents CH, each R¹ independently represents -CH₂COR⁵, R⁵ represents a hydroxy, each R² independently represents ZYR⁶, wherein Z represents a bond or a C_1-3alkylene group, Y represents a bond, R⁶ represents OR⁸ or OP(O)(OR⁸)R⁷, R⁷ represents a hydroxy or an unsubstituted alkyl or aminoalkyl group, R⁸ represents hydrogen or a C_1-6alkyl group, R³ represents an unsubstituted C_1-8alkylene group, and each R⁴ independently represents a C_1-3alkyl. Also proposed is a method for treating a pathological condition in a patient, caused by the presence of free radicals formed from oxygen, including introduction of the above mixed complex compound to the patient.

EFFECT: proposed composition ensures treatment of a pathological condition caused by the presence of free radicals formed from oxygen.

Formula I

30 cl, 35 dwg, 11 ex