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2 813 347

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IPC

C07C211/27(2006-01-01)

A61K31/137(2006-01-01)

A61P9/10(2006-01-01)

(21) (22)

Application

2022121807, 2022-08-09

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Start date

2022-08-09

(22)

Actual filing date

2022-08-09

(45)

Published

2024-02-12

(72)

Inventor

Mokrov Grigorij VladimirovichBarchukov Vladimir ValerevichKryzhanovskij Sergej AleksandrovichBobrovskij Sergej IgorevichVititnova Marina BorisovnaTsorin Iosif BorisovichGudasheva Tatyana Aleksandrovna

(73)

Holder

Federalnoe Gosudarstvennoe Byudzhetnoe Nauchnoe Uchrezhdenie Issledovatelskij Tsentr Originalnykh I Perspektivnykh Biomeditsinskikh I Farmatsevticheskikh Tekhnologij"

ORGANIC SALTS N1-(2,3,4-TRIMETHOXYBENZYL)-N2-{2-[(2,3,4-TRIMETHOXYBENZYL)AMINO]ETHYL}-1,2-ETHANE-DIAMINE Russian patent published in 2024 - IPC C07C211/27 A61K31/137 A61P9/10

Abstract RU 2813347 C2

FIELD: chemistry.

SUBSTANCE: invention relates to a method of producing organic salts N¹-(2,3,4-trimethoxybenzyl)-N²-{2-[(2,3,4-trimethoxybenzyl)amino]ethyl}-1,2-ethane-diamine of the general formula

where n=1.5-2; R-C(O)OH=citric or succinic acid, the base which is N¹-(2,3,4-trimethoxybenzyl)-N²-{2-[(2,3,4-trimethoxybenzyl)amino ]ethyl}-1,2-ethanediamine reacts with an excess of organic acid, such as succinic or citric acid, in solutions of such alcohols as ethanol or isopropanol upon heating, followed by filtration of the precipitate of the desired salt.

EFFECT: development of a method of producing new salts N¹-(2,3,4-trimethoxybenzyl)-N²-{2-[(2,3,4-trimethoxybenzyl)amino]ethyl}-1,2-ethane-diamine, namely, succinate and citrate, which are low-toxic and can be used in medicine as agents with cardiotropic activity.

1 cl, 4 tbl, 4 ex

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RU 2 813 347 C2

Authors

Mokrov Grigorij Vladimirovich

Barchukov Vladimir Valerevich

Kryzhanovskij Sergej Aleksandrovich

Bobrovskij Sergej Igorevich

Vititnova Marina Borisovna

Tsorin Iosif Borisovich

Gudasheva Tatyana Aleksandrovna

Dates

2024-02-12—Published

2022-08-09—Filed