FIELD: chemistry.
SUBSTANCE: invention relates to a process for the preparation of benzyl (1,2-diphenyl-1,2-etandion) (1) 
which can be used as a precursor for the synthesis of "Phenytoin" antiepileptic drug derivatives of hydantoin group which renders anticonvulsant action without significant hypnotic effect, and is also used as an antiarrhythmic. The method consists in that the methyl ester of benzoic acid (MEBA) is reacted with EtAlCl2 In the presence of magnesium (Mg, powder) and catalyst Cp2TiCl2 in the molar ratio of MEBA: EtAlCl2:Mg:Cp2TiCl2= 10: (20-40): 20: (0.8-1.2) in tetrahydrofuran under argon at 60°C and atmospheric pressure for 6 hours.
EFFECT: method enables to obtain the end product with high output.
1 tbl, 7 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF PRODUCING 1,2-DIARYLETHANE-1,2-DIONES | 2024 |
|
RU2841326C1 |
| METHOD OF PRODUCING 2,3-DIALKYL-1,4-DICYCLOPROPYL-1,4-BUTANEDIONES | 2014 |
|
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| METHOD OF OBTAINING TETRAALKYL-SUBSTITUTED FURANS | 2012 |
|
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| PRODUCTION PROCESS OF 2,3,5,6-TETRAFENYL(BENZYL)PYRASINE | 2017 |
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|
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| PROCESS FOR THE PREPARATION OF 3-ALKYL(PHENYL)-2,5-DIPHENYL-1H-PYRROLES | 2017 |
|
RU2677470C2 |
| METHOD FOR METHYL n-[3,4-DIALKYL-5-(n-METHOXY-n-OXOALKYL)-2-FURYL] ALKANOATES PRODUCTION | 2015 |
|
RU2614250C2 |
| 2,3-DIALKYL-2-CYCLOOCTENE-1-ONE PREPARATION PROCESS | 2016 |
|
RU2664661C2 |
| METHOD OF JOINT RECOVERY OF 2,3-DIALKYL-2-CYCLOHEPTENE-1-ONES AND 2,3-DIALKYL-2-CYCLOHEPTENE-1,4-DIONES | 2015 |
|
RU2624904C2 |
