FIELD: pharmacology.
SUBSTANCE: composition contains 2-[(1Z)-1-(3,5-diphenyl-1,3,4-thiadiazol-2(3H)-ylidene chloride)methyl]-3,5-diphenyl-1,3,4-tiadiazol-3-th (TDZ) in an amount of 15 to 50 wt %, Polyethylene oxide, in an amount of 15 to 50 wt %, Poloxamer, in an amount of 5 to 20 wt % Lecithin, in an amount of 1 to 5 wt %, and pharmaceutically acceptable excipients. According to the process for preparing the composition, the TPD is dissolved in ethyl or isopropyl alcohol, methylene chloride or mixtures thereof, polyethylene oxide, poloxamer and lecithin are introduced into the solution, then other pharmaceutically acceptable excipients are added to the mixture, the mixture is dried, granulated, and tablets or capsules are prepared.
EFFECT: inventions allow to increase the release of the active substance from the tablet or granules and to improve the antifungal activity of the substance.
6 cl, 1 dwg, 3 tbl, 6 ex
