FIELD: medicine.
SUBSTANCE: to determine the effectiveness of new treatments for the disease, periodontitis is simulated by introducing substances, providing immunodepressivne effect to mature "Wistar" rats, with subsequent imposition of tooth ligatures for 14 days, while feeding the animals with soft food. As a immunosuppressive substance, prednisolone is administered intramuscularly at the rate of 12 mg/kg of animal weight on the 1st, 3rd and 5th days of experiment. At that, the ligature is applied to the second molar of the upper jaw on the 5th day.
EFFECT: ensured stability of traumatic factor action and facilitation of plaque formation by preventing ligature displacement at accelerated development of inflammation.
4 dwg, 3 tbl, 1 ex
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