METHOD TO INCREASE ETEC CS6 ANTIGEN PRESENTATION ON CELLULAR SURFACE AND PRODUCTS OBTAINED BASED THEREON Russian patent published in 2017 - IPC A61K39/108 C12N1/20 A61P31/04

Abstract RU 2628698 C2

FIELD: chemistry.

SUBSTANCE: invention relates to a method to increase CS6 ETEC antigen presentation on a cellular surface, which can be used in medicine. A method for production of inactivated whole-cell vaccine for oral immunization against CS6-expressing ETEC comprises the step of contacting of cells expressing the said antigen with an aqueous solution containing 0.6-2.2% phenol by weight, with contact time of 1.5 to 42 hours and a temperature of 18 to 42°C.

EFFECT: invention allows to increase the presentation of the said antigen by at least 100 percent.

14 cl, 3 dwg, 4 tbl, 5 ex

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RU 2 628 698 C2

Authors

Karlin Nils

Svennerkholm Ann-Mari

Tobias Joshua

Dates

2017-08-21—Published

2012-09-10—Filed